ea0029p37 | Adrenal cortex | ICEECE2012
Bandulik S.
, Tauber P.
, Penton-Ribas D.
, Tegtmeier I.
, Lesage F.
, Barhanin J.
, Warth R.
Depolarisation of adrenal zona glomerulosa cells is a pivotal event for the secretion of aldosterone. Potassium channels like TASK1 and TASK3 are highly expressed in the adrenal cortex and determine the membrane voltage. Deletion of TASK3 K+ channels in mice caused a severe age-dependent hyperaldosteronism. The aim of this study was to identify the mechanisms underlying this phenotype.Neonatal TASK3-/- mice (ko) showed higher plasma aldosteron...